Chronic High Glucose and Pyruvate Levels Differentially Affect Mitochondrial Bioenergetics and Fuel-stimulated Insulin Secretion from Clonal INS-1 832/13 Cells

Glucotoxicity in pancreatic β-cells is a well established pathogenetic process in type 2 diabetes. It has been suggested that metabolism-derived reactive oxygen species perturb the β-cell transcriptional machinery. Less is known about altered mitochondrial function in this condition. We used INS-1 8...

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Bibliographische Detailangaben
Hauptverfasser: Göhring, Isabel, Sharoyko, Vladimir V., Malmgren, Siri, Andersson, Lotta E., Spégel, Peter, Nicholls, David G., Mulder, Hindrik
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916575/
https://ncbi.nlm.nih.gov/pubmed/24356960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.507335
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