Tight Coupling between Glucose and Mitochondrial Metabolism in Clonal β-Cells Is Required for Robust Insulin Secretion

The biochemical mechanisms underlying glucose-stimulated insulin secretion from pancreatic β-cells are not completely understood. To identify metabolic disturbances in β-cells that impair glucose-stimulated insulin secretion, we compared two INS-1-derived clonal β-cell lines, which are glucose-respo...

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Detalhes bibliográficos
Main Authors: Malmgren, Siri, Nicholls, David G., Taneera, Jalal, Bacos, Karl, Koeck, Thomas, Tamaddon, Ashkan, Wibom, Rolf, Groop, Leif, Ling, Charlotte, Mulder, Hindrik, Sharoyko, Vladimir V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Metabolism and Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781654/
https://ncbi.nlm.nih.gov/pubmed/19797055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.026708
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