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Posttranslational Modifications of the Retinoblastoma Tumor Suppressor Protein as Determinants of Function

The retinoblastoma tumor suppressor protein (pRB) plays an integral role in G(1)-S checkpoint control and consequently is a frequent target for inactivation in cancer. The RB protein can function as an adaptor, nucleating components such as E2Fs and chromatin regulating enzymes into the same complex...

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Detalhes bibliográficos
Main Authors: MacDonald, James I., Dick, Frederick A.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636757/
https://ncbi.nlm.nih.gov/pubmed/23634251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912473305
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