Neprilysin Deficiency Protects Against Fat-Induced Insulin Secretory Dysfunction by Maintaining Calcium Influx

Neprilysin contributes to free fatty acid (FFA)-induced cellular dysfunction in nonislet tissues in type 2 diabetes. Here, we show for the first time that with prolonged FFA exposure, islet neprilysin is upregulated and this is associated with reduced insulin pre-mRNA and ATP levels, oxidative/nitra...

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Bibliografiske detaljer
Main Authors: Zraika, Sakeneh, Koh, Duk-Su, Barrow, Breanne M., Lu, Bao, Kahn, Steven E., Andrikopoulos, Sofianos
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636612/
https://ncbi.nlm.nih.gov/pubmed/23328128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1593
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