Neprilysin Deficiency Protects Against Fat-Induced Insulin Secretory Dysfunction by Maintaining Calcium Influx

Neprilysin contributes to free fatty acid (FFA)-induced cellular dysfunction in nonislet tissues in type 2 diabetes. Here, we show for the first time that with prolonged FFA exposure, islet neprilysin is upregulated and this is associated with reduced insulin pre-mRNA and ATP levels, oxidative/nitra...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zraika, Sakeneh, Koh, Duk-Su, Barrow, Breanne M., Lu, Bao, Kahn, Steven E., Andrikopoulos, Sofianos
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Diabetes Association 2013
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636612/
https://ncbi.nlm.nih.gov/pubmed/23328128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1593
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