Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity

AIMS/HYPOTHESIS: Recently, the novel myokine irisin was described to drive adipose tissue ‘browning’, to increase energy expenditure, and to improve obesity and insulin resistance in high fat-fed mice. Here, we assessed whether common single nucleotide polymorphisms (SNPs) in the FNDC5 locus, encodi...

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Autori principali: Staiger, Harald, Böhm, Anja, Scheler, Mika, Berti, Lucia, Machann, Jürgen, Schick, Fritz, Machicao, Fausto, Fritsche, Andreas, Stefan, Norbert, Weigert, Cora, Krook, Anna, Häring, Hans-Ulrich, de Angelis, Martin Hrabě
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636229/
https://ncbi.nlm.nih.gov/pubmed/23637927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061903
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