Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants

The PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase, and pink1 mutations cause early onset Parkinson's disease (PD) in humans. Loss of pink1 in Drosophila leads to defects in mitochondrial function, and genetic data suggest that another PD-related gene product, Parkin, acts with pink1 t...

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Hlavní autoři: Esposito, Giovanni, Vos, Melissa, Vilain, Sven, Swerts, Jef, De Sousa Valadas, Jorge, Van Meensel, Stefanie, Schaap, Onno, Verstreken, Patrik
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636082/
https://ncbi.nlm.nih.gov/pubmed/23637640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003478
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