Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants

The PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase, and pink1 mutations cause early onset Parkinson's disease (PD) in humans. Loss of pink1 in Drosophila leads to defects in mitochondrial function, and genetic data suggest that another PD-related gene product, Parkin, acts with pink1 t...

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Bibliografiske detaljer
Main Authors: Esposito, Giovanni, Vos, Melissa, Vilain, Sven, Swerts, Jef, De Sousa Valadas, Jorge, Van Meensel, Stefanie, Schaap, Onno, Verstreken, Patrik
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636082/
https://ncbi.nlm.nih.gov/pubmed/23637640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003478
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