Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF

Activating mutations in BRAF are the most common genetic alterations in melanoma. Inhibition of BRAF by small molecule inhibitors leads to cell cycle arrest and apoptosis. We show here that BRAF inhibition also induces an oxidative phosphorylation gene program, mitochondrial biogenesis, and the incr...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Haq, Rizwan, Shoag, Jonathan, Andreu-Perez, Pedro, Yokoyama, Satoru, Edelman, Hannah, Rowe, Glenn C., Frederick, Dennie T., Hurley, Aeron D., Nellore, Abhinav, Kung, Andrew L., Wargo, Jennifer A., Song, Jun S., Fisher, David E., Arany, Zolt, Widlund, Hans R.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635826/
https://ncbi.nlm.nih.gov/pubmed/23477830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.02.003
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker