Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF

Activating mutations in BRAF are the most common genetic alterations in melanoma. Inhibition of BRAF by small molecule inhibitors leads to cell cycle arrest and apoptosis. We show here that BRAF inhibition also induces an oxidative phosphorylation gene program, mitochondrial biogenesis, and the incr...

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Hlavní autoři: Haq, Rizwan, Shoag, Jonathan, Andreu-Perez, Pedro, Yokoyama, Satoru, Edelman, Hannah, Rowe, Glenn C., Frederick, Dennie T., Hurley, Aeron D., Nellore, Abhinav, Kung, Andrew L., Wargo, Jennifer A., Song, Jun S., Fisher, David E., Arany, Zolt, Widlund, Hans R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635826/
https://ncbi.nlm.nih.gov/pubmed/23477830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.02.003
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