The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases

Increased airway smooth muscle (ASM) contractility and the development of airway hyperresponsiveness (AHR) are cardinal features of asthma, but the signaling pathways that promote these changes are poorly understood. Tyrosine phosphorylation is tightly regulated by the opposing actions of protein ty...

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Autori principali: Katsumoto, Tamiko R., Kudo, Makoto, Chen, Chun, Sundaram, Aparna, Callahan, Elliott C., Zhu, Jing W., Lin, Joseph, Rosen, Connor E., Manz, Boryana N., Lee, Jae W., Matthay, Michael A., Huang, Xiaozhu, Sheppard, Dean, Weiss, Arthur
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635736/
https://ncbi.nlm.nih.gov/pubmed/23543053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66397
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