Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice

Chronic pancreatitis is an inflammatory disease that causes progressive destruction of pancreatic acinar cells and, ultimately, loss of pancreatic function. We investigated the role of IκB kinase α (IKKα) in pancreatic homeostasis. Pancreas-specific ablation of IKKα (Ikkα(Δpan)) caused spontaneous a...

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Xehetasun bibliografikoak
Egile Nagusiak: Li, Ning, Wu, Xuefeng, Holzer, Ryan G., Lee, Jun-Hee, Todoric, Jelena, Park, Eek-Joong, Ogata, Hisanobu, Gukovskaya, Anna S., Gukovsky, Ilya, Pizzo, Donald P., VandenBerg, Scott, Tarin, David, Atay, Çiǧdem, Arkan, Melek C., Deerinck, Thomas J., Moscat, Jorge, Diaz-Meco, Maria, Dawson, David, Erkan, Mert, Kleeff, Jörg, Karin, Michael
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2013
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635720/
https://ncbi.nlm.nih.gov/pubmed/23563314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64498
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