Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice

Chronic pancreatitis is an inflammatory disease that causes progressive destruction of pancreatic acinar cells and, ultimately, loss of pancreatic function. We investigated the role of IκB kinase α (IKKα) in pancreatic homeostasis. Pancreas-specific ablation of IKKα (Ikkα(Δpan)) caused spontaneous a...

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Detalhes bibliográficos
Main Authors: Li, Ning, Wu, Xuefeng, Holzer, Ryan G., Lee, Jun-Hee, Todoric, Jelena, Park, Eek-Joong, Ogata, Hisanobu, Gukovskaya, Anna S., Gukovsky, Ilya, Pizzo, Donald P., VandenBerg, Scott, Tarin, David, Atay, Çiǧdem, Arkan, Melek C., Deerinck, Thomas J., Moscat, Jorge, Diaz-Meco, Maria, Dawson, David, Erkan, Mert, Kleeff, Jörg, Karin, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635720/
https://ncbi.nlm.nih.gov/pubmed/23563314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64498
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