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Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks.
The structure of replicating simian virus 40 minichromosomes, extracted from camptothecin-treated infected cells, was investigated by biochemical and electron microscopic methods. We found that camptothecin frequently induced breaks at replication forks close to the replicative growth points. Replic...
Tallennettuna:
| Julkaisussa: | Mol Cell Biol |
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| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Taylor & Francis
1988
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363528/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2850477/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.8.3026 |
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