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Dabigatran Does Not Prolong the QT Interval with Supratherapeutic Exposure: a Thorough QT Study in Healthy Subjects

BACKGROUND: Dabigatran etexilate is a pro-drug of the oral reversible direct thrombin inhibitor dabigatran that interacts with the active site in the catalytic domain of the thrombin molecule. OBJECTIVE: To assess the electrophysiological effects of therapeutic and supratherapeutic doses of dabigatr...

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Detalhes bibliográficos
Main Authors: Ring, Arne, Rathgen, Karin, Stangier, Joachim, Reilly, Paul, Clemens, Andreas, Friedman, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing AG 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634983/
https://ncbi.nlm.nih.gov/pubmed/23519576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40261-013-0058-0
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