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EGFRvIV: a previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism

Tumor cells often subvert normal regulatory mechanisms of signal transduction. This study shows this principle by studying yet uncharacterized mutants of the epidermal growth factor receptor (EGFR) previously identified in glioblastoma multiforme, which is the most aggressive brain tumor in adults....

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Detalhes bibliográficos
Main Authors: Pines, G, Huang, PH, Zwang, Y, White, FM, Yarden, Y
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634975/
https://ncbi.nlm.nih.gov/pubmed/20676128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.313
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