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Oncogenic mutant forms of EGFR: lessons in signal transduction and targets for cancer therapy

The EGF receptor is frequently mutated in a large variety of tumors. Here we review the most frequent mutations and conclude that they commonly enhance the intrinsic tyrosine kinase activity, or they represent loss-of-function of suppressive regulatory domains. Interestingly, the constitutive activi...

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Autori principali: Pines, Gur, Köstler, Wolfgang J., Yarden, Yosef
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892754/
https://ncbi.nlm.nih.gov/pubmed/20388509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.04.019
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