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Oncogenic mutant forms of EGFR: lessons in signal transduction and targets for cancer therapy
The EGF receptor is frequently mutated in a large variety of tumors. Here we review the most frequent mutations and conclude that they commonly enhance the intrinsic tyrosine kinase activity, or they represent loss-of-function of suppressive regulatory domains. Interestingly, the constitutive activi...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892754/ https://ncbi.nlm.nih.gov/pubmed/20388509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.04.019 |
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