Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation

Th2-driven lung inflammation increases Arginase 1 (Arg1) expression in alternatively-activated macrophages (AAMs). AAMs modulate T cell and wound healing responses and Arg1 might contribute to asthma pathogenesis by inhibiting nitric oxide production, regulating fibrosis, modulating arginine metabol...

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Autors principals: Barron, Luke, Smith, Amber M., El Kasmi, Karim C., Qualls, Joseph E., Huang, Xiaozhu, Cheever, Allen, Borthwick, Lee A., Wilson, Mark S., Murray, Peter J., Wynn, Thomas A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634833/
https://ncbi.nlm.nih.gov/pubmed/23637937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061961
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