An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias

PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. The role of PTEN in carcinogenesis has been validated by knockout mouse models. PTEN heterozygous mice develop neoplasms in multiple organs. Unfortunately, the embryonic lethality of biallelic excision of PTEN has in...

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Hoofdauteurs: Mirantes, Cristina, Eritja, Núria, Dosil, Maria Alba, Santacana, Maria, Pallares, Judit, Gatius, Sónia, Bergadà, Laura, Maiques, Oscar, Matias-Guiu, Xavier, Dolcet, Xavier
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Company of Biologists Limited 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634654/
https://ncbi.nlm.nih.gov/pubmed/23471917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.011445
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