Reconstitution of the Anti-Apoptotic Bcl-2 Protein into Lipid Membranes and Biophysical Evidence for Its Detergent-Driven Association with the Pro-Apoptotic Bax Protein

The anti-apoptotic B-cell CLL/lymphoma-2 (Bcl-2) protein and its counterpart, the pro-apoptotic Bcl-2-associated X protein (Bax), are key players in the regulation of the mitochondrial pathway of apoptosis. However, how they interact at the mitochondrial outer membrane (MOM) and there determine whet...

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Bibliographic Details
Main Authors: Wallgren, Marcus, Lidman, Martin, Pedersen, Anders, Brännström, Kristoffer, Karlsson, B. Göran, Gröbner, Gerhard
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634071/
https://ncbi.nlm.nih.gov/pubmed/23626686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061452
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