The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-x(L)

BACKGROUND: Bcl-2 family proteins are key regulators of mitochondrial integrity and comprise both pro- and anti-apoptotic proteins. Bax a pro-apoptotic member localizes as monomers in the cytosol of healthy cells and accumulates as oligomers in mitochondria of apoptotic cells. The Bcl-2 homology-3 (...

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Detalhes bibliográficos
Main Authors: Parikh, Neha, Koshy, Caroline, Dhayabaran, Vaigundan, Perumalsamy, Lakshmi R, Sowdhamini, R, Sarin, Apurva
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890283/
https://ncbi.nlm.nih.gov/pubmed/17519046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-8-16
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