Severe Liver Cirrhosis Markedly Reduces AhR-Mediated Induction of Cytochrome P450 in Rats by Decreasing the Transcription of Target Genes

Although the induction of cytochrome P450 (CYP) has long been investigated in patients with cirrhosis, the question whether liver dysfunction impairs the response to CYP inducers still remains unresolved. Moreover, the mechanism underlying the possible effect of cirrhosis on induction has not been i...

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Main Authors: Floreani, Maura, De Martin, Sara, Gabbia, Daniela, Barbierato, Massimo, Nassi, Alberto, Mescoli, Claudia, Orlando, Rocco, Bova, Sergio, Angeli, Paolo, Gola, Elisabetta, Sticca, Antonietta, Palatini, Pietro
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633963/
https://ncbi.nlm.nih.gov/pubmed/23626760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061983
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