Activation of mTOR Ameliorates Fragile X Premutation rCGG Repeat-Mediated Neurodegeneration

Fragile X associated tremor/ataxia syndrome (FXTAS) is a late onset neurodegenerative disorder caused by aberrant expansion of CGG repeats in 5′ UTR of FMR1 gene. The elevated mRNA confers a toxic gain-of-function thought to be the critical event of pathogenesis. Expressing rCGG(90) repeats of the h...

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Bibliografiske detaljer
Main Authors: Lin, Yunting, Tang, Chengyuan, He, Hua, Duan, Ranhui
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633886/
https://ncbi.nlm.nih.gov/pubmed/23626835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062572
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