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Activation of mTOR Ameliorates Fragile X Premutation rCGG Repeat-Mediated Neurodegeneration
Fragile X associated tremor/ataxia syndrome (FXTAS) is a late onset neurodegenerative disorder caused by aberrant expansion of CGG repeats in 5′ UTR of FMR1 gene. The elevated mRNA confers a toxic gain-of-function thought to be the critical event of pathogenesis. Expressing rCGG(90) repeats of the h...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3633886/ https://ncbi.nlm.nih.gov/pubmed/23626835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062572 |
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