Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a progressive neurodegenerative disorder recognized in fragile X premutation carriers. Using Drosophila, we previously identified elongated non-coding CGG repeats in FMR1 allele as the pathogenic cause of FXTAS. Here, we use this same FXTAS Dros...

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Main Authors: Qurashi, Abrar, Liu, Huijie, Ray, Laurie, Nelson, David L., Duan, Ranhui, Jin, Peng
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315210/
https://ncbi.nlm.nih.gov/pubmed/22298836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds024
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