Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia

Previously, we observed significant increases in spinal 12-lipoxygenase (LOX) metabolites, in particular, hepoxilins, which contribute to peripheral inflammation-induced tactile allodynia. However, the enzymatic sources of hepoxilin synthase (HXS) activity in rats remain elusive. Therefore, we overe...

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Bibliografiska uppgifter
Huvudupphovsmän: Gregus, Ann M., Dumlao, Darren S., Wei, Spencer C., Norris, Paul C., Catella, Laura C., Meyerstein, Flore G., Buczynski, Matthew W., Steinauer, Joanne J., Fitzsimmons, Bethany L., Yaksh, Tony L., Dennis, Edward A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Federation of American Societies for Experimental Biology 2013
Ämnen:
Research Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633813/
https://ncbi.nlm.nih.gov/pubmed/23382512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-217414
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