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In vivo maturation of allo-specific CD8 CTL and prevention of lupus-like graft-vs.-host disease is critically dependent on T cell signaling through the TNF p75 receptor but not the TNF p55 receptor
A third signal is required for maturation of effector CD8 CTL in addition to TCR and CD28 engagement. Inflammatory cytokines can provide a third signal however in non-pathogen settings (i.e. anti-tumor responses), the identity of the third signal is not clear. A useful model for in vivo CD8 CTL in t...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3633743/ https://ncbi.nlm.nih.gov/pubmed/23526821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300091 |
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