Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca2+ signaling in Huntington’s disease

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by an expanded trinucleotide CAG repeat in the gene coding for huntingtin (Htt). Deregulation of chromatin remodeling is linked to the pathogenesis of HD but the mechanism remains elusive. In order to identify what g...

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Autores principales: Lee, Junghee, Hwang, Yu Jin, Shin, Jong-Yeon, Lee, Won-Chul, Wie, Jinhong, Kim, Ki Yoon, Lee, Min Young, Hwang, Daehee, Ratan, Rajiv R., Pae, Ae Nim, Kowall, Neil W., So, Insuk, Kim, Jong-Il, Ryu, Hoon
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633717/
https://ncbi.nlm.nih.gov/pubmed/23455440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1103-z
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