A two-step database search method improves sensitivity in peptide sequence matches for metaproteomics and proteogenomics studies

Large databases (> 10(6) sequences) used in metaproteomic and proteogenomic studies present challenges in matching peptide sequences to tandem MS data using database-search programs. Most notably, strict filtering to avoid false positive matches leads to more false negatives, thus constraining th...

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Bibliographic Details
Main Authors: Jagtap, Pratik, Goslinga, Jill, Kooren, Joel A., McGowan, Thomas, Wroblewski, Matthew S., Seymour, Sean L., Griffin, Timothy J.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633484/
https://ncbi.nlm.nih.gov/pubmed/23412978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201200352
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