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A two-step database search method improves sensitivity in peptide sequence matches for metaproteomics and proteogenomics studies
Large databases (> 10(6) sequences) used in metaproteomic and proteogenomic studies present challenges in matching peptide sequences to tandem MS data using database-search programs. Most notably, strict filtering to avoid false positive matches leads to more false negatives, thus constraining th...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3633484/ https://ncbi.nlm.nih.gov/pubmed/23412978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201200352 |
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