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An NKp30-based chimeric antigen receptor promotes T-cell effector functions and anti-tumor efficacy in vivo

NKp30 is a natural cytotoxicity receptor (NCR) that is expressed on natural killer (NK) cells and recognizes B7-H6, which is expressed on several types of tumors but few normal cells. To target effector T cells against B7-H6-positive tumors, we have developed several chimeric antigen receptors (CAR)...

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Autori principali: Zhang, Tong, Wu, Ming-Ru, Sentman, Charles L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633481/
https://ncbi.nlm.nih.gov/pubmed/22851709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103495
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