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DNA replication timing and higher-order nuclear organization determine single nucleotide substitution patterns in cancer genomes
Single nucleotide substitutions (SNS) are a defining characteristic of cancer genomes. Many SNS in cancer genomes arise due to errors in DNA replication, which is spatio-temporally stratified. Here we propose that DNA replication patterns help shape the mutational landscapes of normal and cancer gen...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3633418/ https://ncbi.nlm.nih.gov/pubmed/23422670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2502 |
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