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Zic3 is required in the migrating primitive streak for node morphogenesis and left–right patterning
In humans, loss-of-function mutations in ZIC3 cause isolated cardiovascular malformations and X-linked heterotaxy, a disorder with abnormal left–right asymmetry of organs. Zic3 null mice recapitulate the human heterotaxy phenotype but also have early gastrulation defects, axial patterning defects an...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3633368/ https://ncbi.nlm.nih.gov/pubmed/23303524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt001 |
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