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An essential and highly conserved role for Zic3 in left-right patterning, gastrulation and convergent extension morphogenesis
Mutations in ZIC3 result in X-linked heterotaxy in humans, a syndrome consisting of left-right (L-R) patterning defects, midline abnormalities, and cardiac malformations. Similarly, loss of function of Zic3 in mouse results in abnormal L-R patterning and cardiac development. However, Zic3 null mice...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3294024/ https://ncbi.nlm.nih.gov/pubmed/22285814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2012.01.011 |
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