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Free Glycine Accelerates the Autoproteolytic Activation of Human Asparaginase

Human asparaginase 3 (hASNase3), which belongs to the N-terminal nucleophile (Ntn) hydrolase superfamily, is synthesized as a single polypeptide that is devoid of asparaginase activity. Intramolecular autoproteolytic processing releases the amino group of Thr168, a moiety required for catalyzing asp...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Su, Ying, Karamitros, Christos S., Nomme, Julian, McSorley, Theresa, Konrad, Manfred, Lavie, Arnon
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633088/
https://ncbi.nlm.nih.gov/pubmed/23601642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.03.006
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