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Mutational Activation of the AmgRS Two-Component System in Aminoglycoside-Resistant Pseudomonas aeruginosa

The amgRS operon encodes a presumed membrane stress-responsive two-component system linked to intrinsic aminoglycoside resistance in Pseudomonas aeruginosa. Genome sequencing of a lab isolate showing modest pan-aminoglycoside resistance, strain K2979, revealed a number of mutations, including a subs...

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Main Authors: Lau, Calvin Ho-Fung, Fraud, Sebastien, Jones, Marcus, Peterson, Scott N., Poole, Keith
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632935/
https://ncbi.nlm.nih.gov/pubmed/23459488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00170-13
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