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Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component System

A screen for agents that potentiated the activity of paromomycin (PAR), a 4,5-linked aminoglycoside (AG), against wild-type Pseudomonas aeruginosa identified the RNA polymerase inhibitor rifampin (RIF). RIF potentiated additional 4,5-linked AGs, such as neomycin and ribostamycin, but not the clinica...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Poole, Keith, Gilmour, Christie, Farha, Maya A., Mullen, Erin, Lau, Calvin Ho-Fung, Brown, Eric D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879422/
https://ncbi.nlm.nih.gov/pubmed/27021319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03069-15
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