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Defects Associated with Mitochondrial DNA Damage Can Be Mitigated by Increased Vacuolar pH in Saccharomyces cerevisiae

While searching for mutations that alleviate detrimental effects of mitochondrial DNA (mtDNA) damage, we found that disrupting vacuolar biogenesis permitted survival of a sensitized yeast background after mitochondrial genome loss. Furthermore, elevating vacuolar pH increases proliferation after mtD...

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Main Authors: Garipler, Görkem, Dunn, Cory D.
Formato: Artigo
Idioma:Inglês
Publicado: Genetics Society of America 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632477/
https://ncbi.nlm.nih.gov/pubmed/23502676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.149708
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