Defects Associated with Mitochondrial DNA Damage Can Be Mitigated by Increased Vacuolar pH in Saccharomyces cerevisiae

While searching for mutations that alleviate detrimental effects of mitochondrial DNA (mtDNA) damage, we found that disrupting vacuolar biogenesis permitted survival of a sensitized yeast background after mitochondrial genome loss. Furthermore, elevating vacuolar pH increases proliferation after mtD...

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Bibliographic Details
Main Authors: Garipler, Görkem, Dunn, Cory D.
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632477/
https://ncbi.nlm.nih.gov/pubmed/23502676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.149708
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