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Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases.

The phosphorylation of the alpha-subunit of initiation factor eIF-2 leads to an inhibition of protein synthesis in mammalian cells. We have performed site-directed mutagenesis on a cDNA encoding the alpha-subunit of human eIF-2 and have replaced the candidate sites of phosphorylation, Ser-48 and Ser...

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Библиографические подробности
Главные авторы: Pathak, V K, Schindler, D, Hershey, J W
Формат: Artigo
Язык:Inglês
Опубликовано: 1988
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC363234/
https://ncbi.nlm.nih.gov/pubmed/3352609
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