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Splicing proofreading at 5′ splice sites by ATPase Prp28p
Fidelity and efficiency of pre-mRNA splicing are critical for generating functional mRNAs, but how such accuracy in 5′ splice site (SS) selection is attained is not fully clear. Through a series of yeast genetic screens, we isolated alleles of prp28 that improve splicing of suboptimal 5′SS substrate...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3632134/ https://ncbi.nlm.nih.gov/pubmed/23462954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt149 |
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