Splicing proofreading at 5′ splice sites by ATPase Prp28p

Fidelity and efficiency of pre-mRNA splicing are critical for generating functional mRNAs, but how such accuracy in 5′ splice site (SS) selection is attained is not fully clear. Through a series of yeast genetic screens, we isolated alleles of prp28 that improve splicing of suboptimal 5′SS substrate...

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Detalles Bibliográficos
Main Authors: Yang, Fei, Wang, Xiu-Ye, Zhang, Zhi-Min, Pu, Jia, Fan, Yu-Jie, Zhou, Jiahai, Query, Charles C., Xu, Yong-Zhen
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
Assuntos:
RNA
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632134/
https://ncbi.nlm.nih.gov/pubmed/23462954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt149
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