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Premature translation termination mediates triosephosphate isomerase mRNA degradation.
We characterized an anemia-inducing mutation in the human gene for triosephosphate isomerase (TPI) that resulted in the production of prematurely terminated protein and mRNA with a reduced cytoplasmic half-life. The mutation converted a CGA arginine codon to a TGA nonsense codon and generated a prot...
Shranjeno v:
| izdano v: | Mol Cell Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Taylor & Francis
1988
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363207/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2832737/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.2.802 |
| Oznake: |
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