Id2-Mediated Inhibition of E2A Represses Memory CD8(+) T Cell Differentiation

The transcription factor inhibitor of DNA binding (Id)2 modulates T cell fate decisions, but the molecular mechanism underpinning this regulation is unclear. In this study we show that loss of Id2 cripples effector differentiation and instead programs CD8(+) T cells to adopt a memory fate with incre...

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Autori principali: Masson, Frederick, Minnich, Martina, Olshansky, Moshe, Bilic, Ivan, Mount, Adele M., Kallies, Axel, Speed, Terence P., Busslinger, Meinrad, Nutt, Stephen L., Belz, Gabrielle T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: AAI 2013
Soggetti:
Immune Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631715/
https://ncbi.nlm.nih.gov/pubmed/23536629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300099
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