Phosphodiesterase-8A binds to and regulates Raf-1 kinase

V-raf-1 murine leukemia viral oncogene homolog 1 (Raf-1) is a key activator of the ERK pathway and is a target for cross-regulation of this pathway by the cAMP signaling system. The cAMP-activated protein kinase, PKA, inhibits Raf-1 by phosphorylation on S259. Here, we show that the cAMP-degrading p...

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Detalhes bibliográficos
Main Authors: Brown, Kim M., Day, Jon P., Huston, Elaine, Zimmermann, Bastian, Hampel, Kornelia, Christian, Frank, Romano, David, Terhzaz, Selim, Lee, Louisa C. Y., Willis, Miranda J., Morton, David B., Beavo, Joseph A., Shimizu-Albergine, Masami, Davies, Shireen A., Kolch, Walter, Houslay, Miles D., Baillie, George S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631629/
https://ncbi.nlm.nih.gov/pubmed/23509299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303004110
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