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Oleoyl-L-carnitine inhibits glycine transport by GlyT2

BACKGROUND AND PURPOSE: Concentrations of extracellular glycine in the CNS are regulated by two Na(+)/Cl(–)-dependent glycine transporters, GlyT1 and GlyT2. Selective inhibitors of GlyT1 have been developed for the treatment of schizophrenia, whilst selective inhibitors of GlyT2 are analgesic in ani...

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Autors principals: Carland, JE, Mansfield, RE, Ryan, RM, Vandenberg, RJ
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631378/
https://ncbi.nlm.nih.gov/pubmed/22978602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02213.x
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