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Toxic Effect of Silica Nanoparticles on Endothelial Cells through DNA Damage Response via Chk1-Dependent G2/M Checkpoint

Silica nanoparticles have become promising carriers for drug delivery or gene therapy. Endothelial cells could be directly exposed to silica nanoparticles by intravenous administration. However, the underlying toxic effect mechanisms of silica nanoparticles on endothelial cells are still poorly unde...

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Detalhes bibliográficos
Main Authors: Duan, Junchao, Yu, Yongbo, Li, Yang, Yu, Yang, Li, Yanbo, Zhou, Xianqing, Huang, Peili, Sun, Zhiwei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631220/
https://ncbi.nlm.nih.gov/pubmed/23620807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062087
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