Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2

Interferon regulatory factor 5-deficient (IRF5 (−/−)) mice have been used for many studies of IRF5 biology. A recent report identifies a mutation in dedicator of cytokinesis 2 (DOCK2) as being responsible for the abnormal B-cell development phenotype observed in the IRF5 (−/−) line. Both dedicator o...

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Detalhes bibliográficos
Main Authors: Yasuda, Kei, Nündel, Kerstin, Watkins, Amanda A., Dhawan, Tania, Bonegio, Ramon G., Ubellacker, Jessalyn M., Marshak-Rothstein, Ann, Rifkin, Ian R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631000/
https://ncbi.nlm.nih.gov/pubmed/23291967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxs114
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