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RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair
BRCA1 promotes homologous recombination repair and antagonizes 53BP1-dependent nonhomologous end joining (NHEJ) pathway. However, the molecular basis of the competition between BRCA1 and 53BP1 pathways remains elusive. Here we report that RIF1 protein translocates to damage sites via ATM-dependent 5...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3630874/ https://ncbi.nlm.nih.gov/pubmed/23486525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.457440 |
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