RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair

BRCA1 promotes homologous recombination repair and antagonizes 53BP1-dependent nonhomologous end joining (NHEJ) pathway. However, the molecular basis of the competition between BRCA1 and 53BP1 pathways remains elusive. Here we report that RIF1 protein translocates to damage sites via ATM-dependent 5...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Feng, Lin, Fong, Ka-Wing, Wang, Jiadong, Wang, Wenqi, Chen, Junjie
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
DNA and Chromosomes
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630874/
https://ncbi.nlm.nih.gov/pubmed/23486525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.457440
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