Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD

Secondary point mutations in the Fms-like tyrosine kinase 3 (FLT3) tyrosine kinase domain (KD) are common causes of acquired clinical resistance to the FLT3 inhibitors AC220 (quizartinib) and sorafenib. Ponatinib (AP24534) is a multikinase inhibitor with in vitro and clinical activity in tyrosine ki...

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Main Authors: Smith, Catherine C., Lasater, Elisabeth A., Zhu, Xiaotian, Lin, Kimberly C., Stewart, Whitney K., Damon, Lauren E., Salerno, Sara, Shah, Neil P.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2013
主題:
Myeloid Neoplasia
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630831/
https://ncbi.nlm.nih.gov/pubmed/23430109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-442871
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