Model-based treatment optimization of a novel VEGFR inhibitor

AIM: To evaluate dosing and intervention strategies for the phase II programme of a VEGF receptor inhibitor using PK–PD modelling and simulation, with the aim of maximizing (i) the number of patients on treatment and (ii) the average dose level during treatment. METHODS: A previously developed PK–PD...

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Bibliographische Detailangaben
Hauptverfasser: Keizer, Ron J., Gupta, Anubha, Shumaker, Robert, Beijnen, Jos H., Schellens, Jan H. M., Huitema, Alwin D. R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2012
Schlagworte:
Pharmacokinetic Dynamic Relationships
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630751/
https://ncbi.nlm.nih.gov/pubmed/22295876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04197.x
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