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Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1

Oxidative stress contributes to the pathogenesis of many diseases, including heart failure, but the role and regulation of oxidative DNA damage in many cases have not been studied. Here, we set out to examine how oxidative DNA damage is regulated in cardiomyocytes. Compared to normal healthy control...

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Autori principali: Siggens, Lee, Figg, Nichola, Bennett, Martin, Foo, Roger
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630495/
https://ncbi.nlm.nih.gov/pubmed/22302830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-197525
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